Chicago

The city of Chicago was Alex Denton and Billie Adams' hometown, and the site of a Tarsus Academy school before the events of Deus ex: Invisible War. A few hours before the game starts, at 5:15 AM, a Nanite bomb is detonated by a Knight Templar near the Tarsus Academy, destroying most of the inner city and killing everyone in range. Students and staff are seen evacuating in helicopters on the roof, which leads to the start of the game in Seattle.