At the beginning of the game, a radical anti-augmentation group called Purity First attacks the manufacturing plant in hopes of finding compromising information on the company. While the attack takes place on a Saturday night many of the employees are there working overtime to meet contract deadlines. The purists take these employees hostage, including Josie and her husband Greg.
After Adam Jensen makes his way through the plant to the administration building, potentially saving Greg and the other hostages from the bomb in the manufacturing level first, he confronts the purists' leader, Zeke Sanders, in Josie's office. Sanders is holding Josie at gunpoint. Josie may be killed by Sanders unless Jensen manages to convince him that he's being used by the augmented hacker who infiltrated his group and that taking a hostage will not save him from the police.
Josie's husband will reward Jensen if he survived the purists' bomb and she was rescued from Zeke Sanders, leading to the side quest One Good Turn Deserves Another.
- Josie's office displays her diploma from Grand Valley Community College, which may be a reference to Grand Valley State University, previously known as Grand Valley State College, in Allendale, Michigan.
- It is possible to fail the conversation with Zeke, which results in him taking Josie hostage and leaving the building. In this scenario Sanders escapes while Josie is killed in the process.
- Her computer password is "
- During development, designers noted that all of the NPCs the player would encounter were of average weight and build. Josie's design was intended to make her more heavy-set.