The middle floor of the 747 contains Lebedev's private quarters, while the lowest floor acts as a storage room. Lebedev's quarters remain locked but a NanoKey found on the upper portion unlocks it.
JC Denton is sent to LaGuardia Airport to track down Lebedev, who is hiding out in his 747. Upon reaching the jet, JC can choose to kill Lebedev or let him live. If JC does not kill him, Anna Navarre will follow JC onto the plane and if not stopped, will kill Lebedev herself. JC must also visit the 747 to complete his secondary mission of locating the stolen Ambrosia barrels. One of these barrels can be found on the lower portion of the plane.
- The 747 makes an appearance in Deus Ex: Invisible War while Alex Denton revisits some of JC Denton's memories.
- The paint job on the plane's rudder is similar to the Soviet Union flag as it features a five-pointed star and an object resembling a sickle.