In 2027, the Skulls have a notable presence in Panama City, operating from the city slums. According to Cobra, the skulls run half of the city and the local police let them be most of the time.
The Illuminati utilize the Skulls to distribute Riezene in Panama City, as part of a field test for the drug. The Skulls receive the drug from Belltower operatives. In return, the Skulls assist Belltower in keeping those who die from the drug off the streets. Belltower's operation in Panama City and its involvement with the Skulls are discovered by Ben Saxon.
- ↑ Dialogue with Diego (if he is persuaded to reveal the Skull's role in distributing RIezene).